Specific high-affinity binding of peripheral benzodiazepine receptor ligands to brain tumors in rat and man

Cancer ◽

10.1002/1097-0142(19900101)65:1<93::aid-cncr2820650120>3.0.co;2-1 ◽

1990 ◽

Vol 65 (1) ◽

pp. 93-97 ◽

Author(s):

Keith L. Black ◽

Kiyonobu Ikezaki ◽

Emily Santori ◽

Donald P. Becker ◽

Harry V. Vinters

Keyword(s):

Brain Tumors ◽

Benzodiazepine Receptor ◽

Affinity Binding ◽

Peripheral Benzodiazepine Receptor ◽

Receptor Ligands ◽

High Affinity Binding ◽

Benzodiazepine Receptor Ligands ◽

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A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation

Journal of Neurochemistry ◽

10.1111/j.1471-4159.2007.04690.x ◽

2007 ◽

Vol 102 (6) ◽

pp. 2118-2131 ◽

Author(s):

Sriram Venneti ◽

Brian J. Lopresti ◽

Guoji Wang ◽

Susan L. Slagel ◽

N. Scott Mason ◽

...

Keyword(s):

Pet Imaging ◽

Microglial Activation ◽

Benzodiazepine Receptor ◽

Peripheral Benzodiazepine Receptor ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands ◽

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Peripheral benzodiazepine receptor ligands induce apoptosis and cell cycle arrest in human hepatocellular carcinoma cells and enhance chemosensitivity to paclitaxel, docetaxel, doxorubicin and the Bcl–2 inhibitor HA14–1

Zeitschrift für Gastroenterologie ◽

10.1055/s-2004-831695 ◽

2004 ◽

Vol 42 (08) ◽

Author(s):

A Sutter ◽

K Maaser ◽

P Grabowski ◽

M Höpfner ◽

A Krahn ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Cell Cycle Arrest ◽

Benzodiazepine Receptor ◽

Carcinoma Cells ◽

Peripheral Benzodiazepine Receptor ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands ◽

Cycle Arrest ◽

Human Hepatocellular Carcinoma Cells

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Benzodiazepine receptor ligands. 8: Synthesis and pharmacological evaluation of new pyrazolo[5,1-c] [1,2,4]benzotriazine 5-oxide 3- and 8-disubstituted: High affinity ligands endowed with inverse-agonist pharmacological efficacy

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2005.08.058 ◽

2006 ◽

Vol 14 (3) ◽

pp. 758-775 ◽

Author(s):

Gabriella Guerrini ◽

Annarella Costanzo ◽

Giovanna Ciciani ◽

Fabrizio Bruni ◽

Silvia Selleri ◽

...

Keyword(s):

Benzodiazepine Receptor ◽

Inverse Agonist ◽

Receptor Ligands ◽

Affinity Ligands ◽

Benzodiazepine Receptor Ligands ◽

High Affinity ◽

Pharmacological Evaluation

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2-Arylpyrazolo[1,5-a]pyrimidin-3-yl acetamides. New potent and selective peripheral benzodiazepine receptor ligands

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(01)00192-4 ◽

2001 ◽

Vol 9 (10) ◽

pp. 2661-2671 ◽

Author(s):

Silvia Selleri ◽

Fabrizio Bruni ◽

Camilla Costagli ◽

Annarella Costanzo ◽

Gabriella Guerrini ◽

...

Keyword(s):

Benzodiazepine Receptor ◽

Peripheral Benzodiazepine Receptor ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands

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Peripheral benzodiazepine receptor ligands induce apoptosis and cell cycle arrest in human hepatocellular carcinoma cells and enhance chemosensitivity to paclitaxel, docetaxel, doxorubicin and the Bcl-2 inhibitor HA14-1

Journal of Hepatology ◽

10.1016/j.jhep.2004.07.015 ◽

2004 ◽

Vol 41 (5) ◽

pp. 799-807 ◽

Author(s):

Andreas P. Sutter ◽

Kerstin Maaser ◽

Patricia Grabowski ◽

Gesine Bradacs ◽

Kirsten Vormbrock ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Cell Cycle Arrest ◽

Benzodiazepine Receptor ◽

Carcinoma Cells ◽

Peripheral Benzodiazepine Receptor ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands ◽

Cycle Arrest ◽

Human Hepatocellular Carcinoma Cells

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3-Phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and Analogues: High-Affinity γ-Aminobutyric Acid-A Benzodiazepine Receptor Ligands with α2, α3, and α5-Subtype Binding Selectivity over α1

Journal of Medicinal Chemistry ◽

10.1021/jm031020p ◽

2004 ◽

Vol 47 (7) ◽

pp. 1807-1822 ◽

Author(s):

Robert W. Carling ◽

Kevin W. Moore ◽

Leslie J. Street ◽

Deborah Wild ◽

Catherine Isted ◽

...

Keyword(s):

Benzodiazepine Receptor ◽

Aminobutyric Acid ◽

Receptor Ligands ◽

Binding Selectivity ◽

Benzodiazepine Receptor Ligands ◽

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Modulation of intracellular calcium in human neutrophils by peripheral benzodiazepine receptor ligands

Journal of Chemotherapy ◽

10.1179/joc.1998.10.2.182 ◽

1998 ◽

Vol 10 (2) ◽

pp. 182-183 ◽

Author(s):

F. Marino ◽

M. Cosentino ◽

S. Cattaneo ◽

L. Di Grazia ◽

E. Caldiroli ◽

...

Keyword(s):

Intracellular Calcium ◽

Benzodiazepine Receptor ◽

Human Neutrophils ◽

Peripheral Benzodiazepine Receptor ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands

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Synthesis of 2-Substituted 2,3-Dihydro-9-phenyl-1H-pyrrolo[3,4-b]quinolin-3-ones as Potential Peripheral Benzodiazepine-Receptor Ligands

Heterocycles ◽

10.3987/com-93-6520 ◽

1994 ◽

Vol 38 (1) ◽

pp. 103 ◽

Author(s):

Andrea Cappelli ◽

Maurizio Anzini ◽

Salvatore Vomero

Keyword(s):

Benzodiazepine Receptor ◽

Peripheral Benzodiazepine Receptor ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands

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Synthesis and structure–activity relationship studies in peripheral benzodiazepine receptor ligands related to alpidem

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2007.06.044 ◽

2008 ◽

Vol 16 (6) ◽

pp. 3428-3437 ◽

Author(s):

Andrea Cappelli ◽

Germano Giuliani ◽

Salvatore Valenti ◽

Maurizio Anzini ◽

Salvatore Vomero ◽

...

Keyword(s):

Benzodiazepine Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Peripheral Benzodiazepine Receptor ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands ◽

Structure Activity

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High affinity central benzodiazepine receptor ligands. Part 2: quantitative structure–activity relationships and comparative molecular field analysis of pyrazolo[4,3- c ]quinolin-3-ones

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(00)00262-5 ◽

2001 ◽

Vol 9 (2) ◽

pp. 431-444 ◽

Author(s):

L. Savini ◽

L. Chiasserini ◽

C. Pellerano ◽

G. Biggio ◽

E. Maciocco ◽

...

Keyword(s):

Benzodiazepine Receptor ◽

Field Analysis ◽

Comparative Molecular Field Analysis ◽

Quantitative Structure ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands ◽

High Affinity ◽

Structure Activity ◽

Central Benzodiazepine Receptor ◽

Quantitative Structure Activity Relationships

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